Document Detail


A Review. Cardiac Pathology and Modern Therapeutic Approach in Behçet Disease.
MedLine Citation:
PMID:  23677721     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Behçet disease is an enigmatic inflammatory disorder with multisystemic manifestations which is induced by a perivasculitis with involvement of both arteries and veins of all sizes. Specific diagnostic and classificatory criteria characterize Behçet disease. The pathology is endemic in many countries but rare cases are encountered everywhere. Cardiovascular involvement is usually mild and asymptomatic. The term cardio-Behçet is used for rare cases with important cardiac complications. Exceptionally, cardiac complications may be the 1st manifestation of Behçet disease. The prevalence of cardio-Behçet in Behçet disease is controversial, but a realistic estimate is in < 10 %. Treatment has been largely improved but still cardio-Behçet carries a high morbidity and poor prognosis. Intra-arterial interventions with the use of stents have reduced some cardiovascular complications. Medical treatment was improved by a better use of colchicine, disease-modifying drugs and immunosuppressive agents. Thromboembolic complications play a major role in the complications of Behçet disease and new oral anticoagulants might exert better therapeutic results. Biological agents have been used and play an important therapeutic role. However, they are expensive, their side-effects are important and the effects of long-term use are poorly known.
Authors:
Giuseppe Cocco; Paul Jerie
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-15
Journal Detail:
Title:  Cardiology journal     Volume:  -     ISSN:  1897-5593     ISO Abbreviation:  Cardiol J     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Formerly Univ. of Ferrara / Italy and University of Basel / Switzerland. Now private practice. praxis@cocco.ch.
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