Document Detail

Review of 1027 patients with newly diagnosed multiple myeloma.
MedLine Citation:
PMID:  12528874     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the clinical and laboratory features of newly diagnosed multiple myeloma.
PATIENTS AND METHODS: Records of all patients in whom multiple myeloma was initially diagnosed at the Mayo Clinic in Rochester, Minn, from January 1, 1985, to December 31, 1998, were reviewed.
RESULTS: Of the 1027 study patients, 2% were younger than 40 years, and 38% were 70 years or older. The median age was 66 years. Anemia was present initially in 73% of patients, hypercalcemia (calcium level > or = 11 mg/dL) in 13%, and a serum creatinine level of 2 mg/dL or more in 19%. The beta2-microglobulin level was increased in 75%. Serum protein electrophoresis revealed a localized band in 82% of patients, and immunoelectrophoresis or immunofixation showed a monoclonal protein in 93%. A monoclonal light chain was found in the urine in 78%. Nonsecretory myeloma was recognized in 3% of patients, whereas light-chain myeloma was present in 20%. Conventional radiographs showed an abnormality in 79%. The plasma cell labeling index was 1% or more in 34% of patients. Multivariate analysis revealed that age, plasma cell labeling index, low platelet count, serum albumin value, and the log of the creatinine value were the most important prognostic factors.
CONCLUSION: The median duration of survival was 33 months and did not improve from 1985 through 1998.
Robert A Kyle; Morie A Gertz; Thomas E Witzig; John A Lust; Martha Q Lacy; Angela Dispenzieri; Rafael Fonseca; S Vincent Rajkumar; Janice R Offord; Dirk R Larson; Matthew E Plevak; Terry M Therneau; Philip R Greipp
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Mayo Clinic proceedings     Volume:  78     ISSN:  0025-6196     ISO Abbreviation:  Mayo Clin. Proc.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-16     Completed Date:  2003-02-05     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0405543     Medline TA:  Mayo Clin Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-33     Citation Subset:  AIM; IM    
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MeSH Terms
Aged, 80 and over
Anemia / etiology
Blood Protein Electrophoresis
Cohort Studies
Creatinine / blood
Diagnosis, Differential
Hypercalcemia / etiology
Medical Records
Middle Aged
Multiple Myeloma / blood,  complications,  diagnosis*,  mortality
Multivariate Analysis
Paraproteinemias / diagnosis
Platelet Count
Predictive Value of Tests
Retrospective Studies
Serum Albumin / metabolism
Survival Analysis
Grant Support
Reg. No./Substance:
0/Serum Albumin; AYI8EX34EU/Creatinine
Comment In:
Mayo Clin Proc. 2003 Jan;78(1):15-7   [PMID:  12528872 ]

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