Document Detail

Reverting antibiotic tolerance of Pseudomonas aeruginosa PAO1 persister cells by (Z)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one.
MedLine Citation:
PMID:  23029239     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Bacteria are well known to form dormant persister cells that are tolerant to most antibiotics. Such intrinsic tolerance also facilitates the development of multidrug resistance through acquired mechanisms. Thus persister cells are a promising target for developing more effective methods to control chronic infections and help prevent the development of multidrug-resistant bacteria. However, control of persister cells is still an unmet challenge.
METHODOLOGY/PRINCIPAL FINDINGS: We show in this report that (Z)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one (BF8) can restore the antibiotic susceptibility of Pseudomonas aeruginosa PAO1 persister cells at growth non-inhibitory concentrations. Persister control by BF8 was found to be effective against both planktonic and biofilm cells of P. aeruginosa PAO1. Interestingly, although BF8 is an inhibitor of quorum sensing (QS) in Gram-negative bacteria, the data in this study suggest that the activities of BF8 to revert antibiotic tolerance of P. aeruginosa PAO1 persister cells is not through QS inhibition and may involve other targets.
CONCLUSION: BF8 can sensitize P. aeruginosa persister cells to antibiotics.
Jiachuan Pan; Ali Adem Bahar; Haseeba Syed; Dacheng Ren
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-09-20
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-02-28     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e45778     Citation Subset:  IM    
Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY, USA.
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MeSH Terms
4-Butyrolactone / analogs & derivatives*,  pharmacology
Analysis of Variance
Anti-Bacterial Agents / pharmacology*
Biofilms / drug effects
Carbenicillin / pharmacology
Ciprofloxacin / pharmacology
Drug Resistance, Bacterial
Drug Synergism
Genes, Bacterial
Gentamicins / pharmacology
Microbial Sensitivity Tests
Oligonucleotide Array Sequence Analysis
Pseudomonas aeruginosa / cytology,  drug effects*,  metabolism,  physiology
Quorum Sensing / drug effects
Tetracycline / pharmacology
Tobramycin / pharmacology
Transcriptome / drug effects
Reg. No./Substance:
0/4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one; 0/Anti-Bacterial Agents; 0/Gentamicins; 32986-56-4/Tobramycin; 4697-36-3/Carbenicillin; 60-54-8/Tetracycline; 85721-33-1/Ciprofloxacin; 96-48-0/4-Butyrolactone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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