| Reversion of severe hepatopulmonary syndrome in a non cirrhotic patient after corticosteroid treatment for granulomatous hepatitis: a case report and review of the literature. | |
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MedLine Citation:
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PMID: 16482641 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatopulmonary syndrome (HPS) is defined as a clinical triad including liver disease, abnormal pulmonary gas exchange and evidence of intrapulmonary vascular dilatations. We report a 61-year-old male presented with fatigue, long-lasting fever, loss of weight, signs of portal hypertension, hepatosplenomegaly, cholestasis and progressive dyspnoea over the last year. Clinical, laboratory and histological findings confirmed the diagnosis of granulomatous hepatitis. HPS due to hepatic granuloma-induced portal hypertension was proved to be the cause of severe hypoxemia of the patient as confirmed by contrast-enhanced echocardiography. Reversion of HPS after corticosteroid therapy was confirmed by a new contrast-enhanced echocardiography along with the normalization of cholestatic enzymes and improvement of the patient's conditions. This is the first case of complete reversion of HPS in a non-cirrhotic patient with hepatic granuloma, indicating that intrapulmonary shunt in liver diseases is a functional phenomenon and HPS can be developed even in miscellaneous liver involvement as in this case. |
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Authors:
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Nikolaos Tzovaras; Aggelos Stefos; Sarah P Georgiadou; Nikolaos Gatselis; Georgia Papadamou; Eirini Rigopoulou; Maria Ioannou; Ioannis Skoularigis; Georgios N Dalekos |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 12 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-02-16 Completed Date: 2006-03-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 336-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, Academic Liver Unit, Medical School, University of Thessaly, Papakiriazi 22 str, 41222 Larissa, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Echocardiography Granuloma / complications, drug therapy* Hepatitis / complications, drug therapy* Hepatopulmonary Syndrome / drug therapy*, etiology, ultrasonography Humans Male Methylprednisolone / therapeutic use* Middle Aged |
| Chemical | |
Reg. No./Substance:
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83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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