Document Detail


Reversing effect of Tanshinone on malignant phenotypes of human hepatocarcinoma cell line.
MedLine Citation:
PMID:  11819308     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM:To study the reversing effect of Chinese drug tanshinone on malignant phenotype of cancer cells.METHODS:Human hepatocarcinoma cell line (SMMC-7721) was treated in vitro with 0.5mg/L tanshinone for 4 days, and variation in cell differentiation wasdetected.RESULTS:The morphology of cancer cells was tended toward well differentiation and cell growth was markedly inhibited. BrdU uptake assay and immunohistochemical stain of PCNA showed that the BrdU labeling rate and PCNA positive rate were lower than the controls, but no difference was found statistically as compared with all transretinoic acid.Flow cytometric assay demonstrated that S phase cells decreased and G(0)/G(1) phase cells increased. Expression of c-myc oncogene protein decreased but the c-fos oncogene protein markedly increased. CONCLUSION:Tanshinone could reverse the inducing differentiation in human hepatocarcinoma cells (SMMC-7721). It may become a new prospective inducer of cell differentiation to treat cancers.
Authors:
Shu-Lan Yuan; Ren-Min Huang; Xiu-Jie Wang; Yi Song; Guang-Qi Huang
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  4     ISSN:  -     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  2002-Jan-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  317-319     Citation Subset:  -    
Affiliation:
Institute of Cancer Research, West China University of Medical Sciences, Chengdu 610041,Sichuan Province, China.
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