Document Detail

Reversible ventricular dysfunction takotsubo cardiomyopathy.
MedLine Citation:
PMID:  16397924     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recently, many cardiologists have recognized the existence of a rapidly reversible form of heart failure of unknown origin characterized by a takotsubo-shaped, dyskinetic left ventricle on left ventriculography.
AIM: To determine the detailed clinical features of takotsubo cardiomyopathy.
METHODS: Thirteen elderly patients (11 women and 2 men with a mean age of 75.3 years) who had normal coronary arteries and takotsubo-like left ventricular dysfunction were prospectively enrolled in this study.
RESULTS: Cardiac enzymes did not increase significantly, but the mean plasma norepinephrine level was very high on admission (0.98 microg/l). Coronary angiography revealed normal coronary arteries in all patients, but left ventriculography showed apical akinesis combined with basal hyperkinesis, i.e., a takotsubo (Japanese octopus fishing pot)-shaped ventricle. Left ventricular wall motion normalized within a mean of 16.9 hospital days in 12 patients, but 1 patient died of acute renal failure on hospital day 7. Cardiac events did not recur during a follow-up period of 0.5 to 5 years.
CONCLUSION: Takotsubo cardiomyopathy seems to be a new type of acute heart failure, which generally has a good prognosis and does not recur. Myocardial damage by catecholamine overload, adrenoceptor hypersensitivity, and changes of catecholamine dynamics due to stress may cause this condition.
Yoshihiro J Akashi; Haruki Musha; Keisuke Kida; Kae Itoh; Koji Inoue; Kensuke Kawasaki; Nobuyuki Hashimoto; Fumihiko Miyake
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of heart failure     Volume:  7     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-01-05     Completed Date:  2006-03-07     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1171-6     Citation Subset:  IM    
Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki-city, Kanagawa-prefecture, Japan.
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MeSH Terms
Aged, 80 and over
Biological Markers / blood
Coronary Angiography
Disease Progression
Follow-Up Studies
Gated Blood-Pool Imaging
Middle Aged
Myocardial Contraction / physiology
Norepinephrine / blood
Prospective Studies
Ventricular Dysfunction, Left / blood,  diagnosis*,  physiopathology
Reg. No./Substance:
0/Biological Markers; 51-41-2/Norepinephrine

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