Document Detail

Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland.
MedLine Citation:
PMID:  15556998     Owner:  NLM     Status:  MEDLINE    
Mammalian breast adipose tissue is replaced by a milk-secreting gland during pregnancy; the reverse process takes place upon interruption of lactation. Morphological and bromodeoxyuridine studies provide indirect evidence that mouse mammary adipocytes transform into secretory epithelial cells during pregnancy and revert to adipocytes after lactation. By using the Cre-loxP recombination system we show that the mammary gland of whey acidic protein (WAP)-Cre/R26R mice, in which secretory epithelial cells express the lacZ gene during pregnancy, contains labeled adipocytes during involution. Conversely, adipocyte P2-Cre/R26R mice, in which adipocytes are labeled before pregnancy, contain labeled secretory epithelial cells during pregnancy. We conclude that reversible adipocyte-to-epithelium and epithelium-to-adipocyte transdifferentiation occurs in the mammary gland of adult mice during pregnancy and lactation.
Manrico Morroni; Antonio Giordano; Maria Cristina Zingaretti; Romina Boiani; Rita De Matteis; Barbara B Kahn; Enzo Nisoli; Cristina Tonello; Catalina Pisoschi; Michele M Luchetti; Mariella Marelli; Saverio Cinti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-11-19
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  101     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-12-01     Completed Date:  2005-01-11     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  16801-6     Citation Subset:  IM    
Institute of Anatomy, School of Medicine, University of Ancona, Via Tronto 10/A, 60020 Ancona, Italy.
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MeSH Terms
Adipocytes / cytology*,  ultrastructure
Base Sequence
Cell Differentiation*
DNA Primers
Epithelial Cells / cytology
Genes, Reporter
Mammary Glands, Animal / cytology*,  ultrastructure
Mice, Transgenic
Microscopy, Electron, Transmission
Reg. No./Substance:
0/DNA Primers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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