| Reversible tracheal obstruction in the fetal sheep: effects on tracheal fluid pressure and lung growth. | |
| | |
MedLine Citation:
|
PMID: 7472976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Congenital diaphragmatic hernia (CDH) continues to carry high morbidity and mortality. A number of treatment modalities including extracorporeal membrane oxygenation and in utero repair have improved the mortality rate only minimally. With this condition, there is often insufficient lung mass at birth and persistent pulmonary hypertension postnatally. Experimental fetal tracheal ligation has been shown to increase lung growth in utero and to reduce the hernial contents in CDH. The purpose of this study was to determine the effect of reversible fetal tracheal occlusion on tracheal pressure and lung development. Nine fetal sheep were divided into two groups. Group 1 had intratracheal balloons placed, and the balloons were left inflated for 21 to 28 days. Group 2 consisted of littermates that served as controls. They either had uninflated balloons placed or were left unoperated. Tracheal pressure measurements were recorded periodically, and the amniotic fluid pressure served as a reference. The animals were killed near term, and the lungs, heart, and liver were weighed and corrected for body weight. Standard morphometry was used to compare the lungs further, and the lung DNA and protein content were measured. Tracheal damage from the balloon catheter also was assessed. The tracheal pressure was 3.85 (+/- .49 SE) mm Hg in experimental animals, and it averaged -0.27 (+/- .27 SE) mm Hg in controls (P < .0001). Tracheal occlusion increased lung weight and volume by two to three times (P < .0001 and P < .0006, respectively) while heart and liver weights remained similar to those of controls.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
E Hashim; J M Laberge; M F Chen; E W Quillen |
Related Documents
:
|
16263476 - Acute lung injury: pathophysiology, assessment and current therapy. 10701706 - Temporal evolution of pneumothorax: respiratory mechanical and histopathological study. 3677486 - Role of pulmonary innervation in canine in situ lung-perfusion preparation: a new model... 7338026 - Regional lung function in children: the accuracy of nitrogen-13 inhalation and infusion... 14694456 - Urgency of voiding and abdominal pressure transmission in women with mixed urinary inco... 16591936 - Effect of gravity on osmotic equilibria. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Journal of pediatric surgery Volume: 30 ISSN: 0022-3468 ISO Abbreviation: J. Pediatr. Surg. Publication Date: 1995 Aug |
Date Detail:
|
Created Date: 1995-12-15 Completed Date: 1995-12-15 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0052631 Medline TA: J Pediatr Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1172-7 Citation Subset: IM |
Affiliation:
|
Department of Surgery, Montreal Children's Hospital, Montreal, Quebec, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amniotic Fluid
/
physiology Animals Balloon Dilatation / adverse effects, instrumentation Body Weight DNA / analysis Embryonic and Fetal Development Exudates and Transudates Female Fetal Diseases / surgery Fetal Organ Maturity Heart / embryology Hernia, Diaphragmatic / embryology, surgery Humans Infant, Newborn Ligation Liver / embryology Lung / chemistry, embryology* Organ Size Persistent Fetal Circulation Syndrome / prevention & control Pregnancy Pressure Proteins / analysis Pulmonary Alveoli / embryology Sheep Trachea / embryology*, injuries, surgery* |
| Chemical | |
Reg. No./Substance:
|
0/Proteins; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gastroschisis: a simple technique for staged silo closure.
Next Document: Combined gas ventilation and perfluorochemical tracheal instillation as an alternative treatment for...