Document Detail


Reversible skin permeabilization for transdermal delivery of macromolecules.
MedLine Citation:
PMID:  9450177     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Great advances in transdermal delivery of macromolecules have been made within the last few years using ultradeformable liposomes, electroporation, and low-frequency ultrasound, each of which has been shown to deliver macromolecules at clinically useful rates. Until recently, delivery of high-molecular-weight compounds across the skin was not a realistic option, since the skin's great barrier properties prevent transport of macromolecules across human skin at therapeutically relevant rates. An overview of chemical (liposomes and chemical enhancers) and physical (iontophoresis, electroporation, and ultrasound) methods of enhancement is presented, with emphasis on work published within the last two years. Key experimental results and their mechanistic interpretation are provided for each enhancement technique.
Authors:
M R Prausnitz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Critical reviews in therapeutic drug carrier systems     Volume:  14     ISSN:  0743-4863     ISO Abbreviation:  Crit Rev Ther Drug Carrier Syst     Publication Date:  1997  
Date Detail:
Created Date:  1998-02-12     Completed Date:  1998-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8511159     Medline TA:  Crit Rev Ther Drug Carrier Syst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  455-83     Citation Subset:  IM    
Affiliation:
School of Chemical Engineering, Georgia Institute of Technology, Atlanta 30332-0100, USA.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Animals
Biological Transport
Drug Delivery Systems*
Electroporation
Humans
Iontophoresis
Liposomes
Permeability
Skin / metabolism*
Ultrasonics
Chemical
Reg. No./Substance:
0/Liposomes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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