Document Detail

Reversible severe congestive cardiomyopathy in three cases of hypophosphatemia.
MedLine Citation:
PMID:  363007     Owner:  NLM     Status:  MEDLINE    
Three patients presented with severe congestive cardiomyopathy of unknown cause. All three had a profound depression of serum phosphorus levels resulting from the chronic ingestion of large quantities of a phosphorus-binding antacid. Results of physical examination and echocardiograms were consistent with cardiomegaly and severe myocardial dysfunction, and chest films showed enlargement of the cardiac silhouette with interstitial pulmonary edema. Serum phosphorus was restored to normal levels, and within 2 to 5 weeks the results of physical examination and echocardiogram of each patient returned to normal. We conclude that these patients had reversible hypophosphatemic cardiomyopathy and show the importance of inorganic phosphorus in myocardial metabolism and function. Serum phosphorus measurements should be a part of the routine evaluation of patients with congestive cardiomyopathy because, at least in some patients, hypophosphatemia appears to be a reversible cause of this disorder.
J R Darsee; D O Nutter
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Publication Detail:
Type:  Case Reports; Journal Article; Retracted Publication    
Journal Detail:
Title:  Annals of internal medicine     Volume:  89     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-01-26     Completed Date:  1979-01-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  867-70     Citation Subset:  AIM; IM    
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MeSH Terms
Antacids / adverse effects
Cardiomyopathies / etiology*
Myocardial Contraction / drug effects
Phosphates / blood*,  pharmacology
Reg. No./Substance:
0/Antacids; 0/Phosphates
Retraction In:
Ann Intern Med. 1983 Aug;99(2):275-6   [PMID:  6349461 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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