Document Detail

Reversible renin-dependent renovascular hypertension successfully treated with percutaneous transluminal renal angioplasty and stenting.
MedLine Citation:
PMID:  15876819     Owner:  NLM     Status:  MEDLINE    
A 37-year old woman was suspected of having renovascular hypertension because of recent onset severe hypertension (blood pressure 220/135 mmHg; compared to 132/65 mmHg two years earlier) and an abdominal bruit. A captopril renal scan indicated the presence of right renal artery stenosis. Additionally, a captopril plasma renin activity (PRA) provocation test showed a positive result for renovascular hypertension (baseline PRA = 291 microU/mL; 1 hour post-captopril PRA = 1444 microU/mL). Selective renal angiography demonstrated a severe critical stenotic lesion at the distal portion of the right renal artery. Blood pressure (BP) decreased to 136/80 mmHg one day after successful percutaneous transluminal renal angioplasty and stenting. Repeat renal angiography six months after the procedure revealed no evidence of in-stent restenosis. Blood pressure (BP = 137/76 mmHg) and plasma renin profile (baseline PRA = 23.8 microU/mL; 1 hour post-captopril PRA=22.3 microu/mL) also were normal six months following initial revascularization. Moreover, blood pressure (137/84 mmHg) and renin profile remained normal 2.5 years after the procedure (baseline PRA = 24.3 microU/mL; 1 hour post-captopril = 25.6 microU/mL). The results of this study have thus demonstrated a case of renin-dependent renovascular hypertension in which both the blood pressure and plasma renin activity profile normalized following successful percutaneous transluminal angioplasty and stenting.
Ber-Ren Fang; Chin-Yew Lin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International heart journal     Volume:  46     ISSN:  1349-2365     ISO Abbreviation:  -     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-05-06     Completed Date:  2005-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244240     Medline TA:  Int Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  339-45     Citation Subset:  IM    
Division of Cardiology, Chang Gung Memorial Hospital, Keelung, Taiwan, Republic of China.
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MeSH Terms
Angioplasty, Balloon / methods*
Hypertension, Renovascular / blood,  therapy*
Renal Artery / radiography
Renal Artery Obstruction / complications,  radiography
Renin / blood*
Reg. No./Substance:

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