| Reversible pulmonary hypertension associated with vitamin C deficiency. | |
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MedLine Citation:
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PMID: 22796843 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We describe the case of a 40-year-old female patient who developed severe pulmonary hypertension and life-threatening right-sided heart failure in association with dietary scurvy and iron deficiency. Supplementation with oral vitamin C and iron very likely contributed to her complete cure. Scurvy-associated pulmonary arterial hypertension could result from impaired availability of endothelial nitric oxide, but inappropriate activation of the hypoxia-inducible family (HIF) of transcription factors could play an even more important role. HIF coordinates the body's responses to hypoxia, and its activity is regulated by oxygen-dependent prolyl hydroxylases, which need vitamin C and iron as cofactors. Deficiency of these cofactors could lead to uncontrolled HIF activity and pulmonary vasoconstriction responsive to vitamin C and iron administration. |
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Authors:
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Markku Kupari; Janne Rapola |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chest Volume: 142 ISSN: 1931-3543 ISO Abbreviation: Chest Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-07-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 225-7 Citation Subset: AIM; IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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