Document Detail

Reversible pulmonary hypertension associated with vitamin C deficiency.
MedLine Citation:
PMID:  22796843     Owner:  NLM     Status:  In-Data-Review    
We describe the case of a 40-year-old female patient who developed severe pulmonary hypertension and life-threatening right-sided heart failure in association with dietary scurvy and iron deficiency. Supplementation with oral vitamin C and iron very likely contributed to her complete cure. Scurvy-associated pulmonary arterial hypertension could result from impaired availability of endothelial nitric oxide, but inappropriate activation of the hypoxia-inducible family (HIF) of transcription factors could play an even more important role. HIF coordinates the body's responses to hypoxia, and its activity is regulated by oxygen-dependent prolyl hydroxylases, which need vitamin C and iron as cofactors. Deficiency of these cofactors could lead to uncontrolled HIF activity and pulmonary vasoconstriction responsive to vitamin C and iron administration.
Markku Kupari; Janne Rapola
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  142     ISSN:  1931-3543     ISO Abbreviation:  Chest     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  225-7     Citation Subset:  AIM; IM    
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