| Reversible postischemic ventricular dysfunction: biochemical insights. | |
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MedLine Citation:
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PMID: 8461516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myocardial stunning, or reversible postischemic ventricular dysfunction, occurs clinically much more frequently than was originally assumed when this phenomenon was first described in experimental studies. Despite the fact that stunned myocardium may appear histologically normal and have a normal metabolic profile, ventricular contractility is severely impaired. In a number of studies using both global and regional stunning models, we have demonstrated impaired oxygen extraction and abnormal patterns of oxygen consumption. In addition, impaired calcium transport or uptake by the sarcoplasmic reticulum occurs and there is sarcolemmal disruption during stunning despite reversibility of the ischemic injury. Although oxygen free radical production is thought to occur only early during postischemic reflow, the use of oxygen radical scavengers in a model of regional stunning was shown to attenuate the ventricular dysfunction. |
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Authors:
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T J Gardner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiac surgery Volume: 8 ISSN: 0886-0440 ISO Abbreviation: J Card Surg Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-05-06 Completed Date: 1993-05-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8908809 Medline TA: J Card Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 271-4 Citation Subset: IM |
Affiliation:
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Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiomyopathies / etiology*, metabolism, physiopathology* Coronary Circulation / physiology Dogs Free Radicals / metabolism Myocardial Ischemia / physiopathology Oxygen Consumption / physiology* Ventricular Function, Left / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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