Document Detail

Reversible posterior leukoencephalopathy syndrome in childhood: report of nine cases and review of the literature.
MedLine Citation:
PMID:  19809787     Owner:  NLM     Status:  MEDLINE    
Reversible posterior leukoencephalopathy syndrome (RPLS) is recently described disorder with typical radiological findings in the posterior regions of the cerebral hemisphere and cerebellum. Its clinical symptoms include headache, decreased alertness, mental abnormalities, such as confusion, diminished spontaneity of speech, and changed behavior ranging from drowsiness to stupor, seizures, vomiting and abnormalities of visual perception like cortical blindness. RPLS is caused by various heterogeneous factors, the commonest being hypertension, followed by non-hypertensive causes such as eclampsia, renal diseases and immunosuppressive therapy. We presented nine patients with RPLS who had primary diagnoses such as acute post-streptococcal glomerulonephritis, idiopathic hypertension, the performing of intravenous immunoglobulin for infection with crescentic glomerulonephritis, erythrocyte transfusion for severe iron deficiency, L: -asparaginase treatment for acute lymphoblastic leukemia and performing of granulocyte-colony stimulating factor for ulcerative colitis due to neutropenia. Early recognition of RPLS as complication during different diseases and therapy in childhood may facilitate precise diagnosis and appropriate treatment.
Hakan G?m??; H?seyin Per; Sefer Kumanda?; Ali Yikilmaz
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2009-10-07
Journal Detail:
Title:  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology     Volume:  31     ISSN:  1590-3478     ISO Abbreviation:  Neurol. Sci.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-11     Completed Date:  2010-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959175     Medline TA:  Neurol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  125-31     Citation Subset:  IM    
Department of Pediatric Neurology, Kayseri Education and Research Hospital, Talas, Kayseri, Turkey.
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MeSH Terms
Brain / pathology
Diagnosis, Differential
Early Diagnosis
Magnetic Resonance Imaging
Posterior Leukoencephalopathy Syndrome / complications,  diagnosis*,  pathology,  therapy

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