Document Detail

Reversible periictal MRI abnormalities: clinical correlates and long-term outcome in 12 patients.
MedLine Citation:
PMID:  17125968     Owner:  NLM     Status:  MEDLINE    
Although a wide spectrum of reversible periictal magnetic resonance imaging (MRI) abnormalities (RPMA) are being increasingly identified, the clinicians are often in a dilemma about their localization significance. This prompted us to analyze the clinical, MRI, electroencephalographic (EEG) and follow-up data of 12 patients with RPMA seen in a tertiary referral epilepsy center. RPMA occurred after a single or a cluster of focal seizures with or without secondary generalization. The interictal and ictal EEG abnormalities were localized to the site of RPMA in nine patients. RPMA involved areas remote from the site of EEG abnormalities in four patients. We have developed a comprehensive classification to account for the wide spectrum of RPMA involving gray matter, white matter and leptomeninges with or without contrast enhancement or mass effect. Follow-up MRIs showed complete resolution of RPMA in all, except in four patients, who developed residual focal atrophy. During median follow-up period of 3 years, recurrence of RPMA was observed in two patients. Diffusion weighted MRI in two patients and histopathological finding in one patient favored causal role of hypoxia in the pathogenesis of RPMA. Our observations help to understand the electroclinical profile, radiological spectrum, localization significance and natural history of RPMA better.
S Raghavendra; R Ashalatha; T Krishnamoorthy; C Kesavadas; S V Thomas; K Radhakrishnan
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Publication Detail:
Type:  Journal Article     Date:  2006-11-27
Journal Detail:
Title:  Epilepsy research     Volume:  73     ISSN:  0920-1211     ISO Abbreviation:  Epilepsy Res.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-15     Completed Date:  2007-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  129-36     Citation Subset:  IM    
Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695011, Kerala, India.
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MeSH Terms
Anticonvulsants / therapeutic use
Child, Preschool
Epilepsy / drug therapy,  pathology*
Magnetic Resonance Imaging*
Middle Aged
Seizures / pathology*
Tomography, X-Ray Computed
Reg. No./Substance:

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