| Reversible paraneoplastic encephalitis in three patients with ovarian neoplasms. | |
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MedLine Citation:
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PMID: 22268613 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Anti-NMDA receptor encephalitis is a recently described potentially lethal but treatable disorder that often occurs as a paraneoplastic manifestation of ovarian teratomas. We report three women with this disorder who presented with subacute onset of delirium, seizures and autonomic instability. Anti-NMDA receptor antibodies were detectable in the serum or CSF of each patient. Ovarian masses were detected in two patients, and subsequently excised. In the third patient, an empiric bilateral salpingo-oophorectomy was performed and revealed a microscopic neoplasm. All patients experienced slow reversal of the neurological symptoms following surgery and immunotherapy. Our experience supports that prompt syndrome recognition followed by tumor removal and immunotherapy usually results in neurological recovery. |
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Authors:
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Janos L Tanyi; Evelyn B Marsh; Josep Dalmau; Christina S Chu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-24 |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: - ISSN: 1600-0412 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors AOGS© 2012 Nordic Federation of Societies of Obstetrics and Gynecology. |
Affiliation:
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Division of Gynecologic Oncology, Department of Obstetrics and Gynecology University of Pennsylvania Health System, Philadelphia, PA, USA Institute of Biomedical Investigations August Pi i Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain. |
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