Document Detail


Reversible nerve lesions after accidental polychlorinated biphenyl exposure.
MedLine Citation:
PMID:  3923618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several capacitors containing polychlorinated biphenyls (PCB) exploded in a cardboard plant. During the accident, and in the clearing work, several workers were in probable contact with PCB and/or its degradation products. Nausea, intense perspiration, and headache were acute symptoms, which cleared quickly. The 15 men with the greatest exposure were studied neurophysiologically twice, namely, two and six months after the explosion. Motor conduction velocities (MCV) of the right median, ulnar, and peroneal nerves; sensory conduction velocity (SCV) of the right sural nerve; and distal SCVs of the right median and ulnar nerves were measured with skin electrodes. Thirty male workers with a similar age distribution served as referents. Two months after the explosion all SCVs and distal SCVs were slower in the exposed men, and still six months after the explosion the distal SCV of the ulnar nerve and the SCV of the sural nerve were slightly slower among the exposed. However, clear improvement occurred in the distal SCVs during the follow-up. As in many toxic distal axonopathies, the distal SCVs were reversibly impaired after an accidental exposure to PCB fumes. PCB seem to exhibit neurotoxic properties in humans.
Authors:
A M Seppäläinen; P Vuojolahti; O Elo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of work, environment & health     Volume:  11     ISSN:  0355-3140     ISO Abbreviation:  Scand J Work Environ Health     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-07-25     Completed Date:  1985-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7511540     Medline TA:  Scand J Work Environ Health     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  91-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects
Adolescent
Adult
Explosions
Humans
Male
Middle Aged
Nervous System Diseases / chemically induced*
Neural Conduction / drug effects*
Occupational Diseases / chemically induced*
Peripheral Nerves / drug effects
Polychlorinated Biphenyls / blood,  poisoning*
Chemical
Reg. No./Substance:
0/Polychlorinated Biphenyls

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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