Document Detail

Reversible multifocal leukoencephalopathy associated with a nocturnal blood pressure non-dipper pattern.
MedLine Citation:
PMID:  20353314     Owner:  NLM     Status:  MEDLINE    
The majority of cases of leukoencephalopathy related to hypertensive crisis show brain lesions predominantly in the posterior lobe. Such cases are usually classified as reversible posterior leukoencephalopathy syndrome (RPLS). A multifocal distribution pattern is also possible, but occurs seldom. Here we report two patients with extensive white matter lesions that affect the entire brain, related to hypertensive crisis associated with a non-dipper pattern of blood pressure during the night as well as renal dysfunction. This nocturnal blood pressure abnormality may be relevant for the distribution pattern of cerebral white matter lesions and underlines the concept that in these cases a 24-h ambulatory blood pressure monitoring is needed.
Oliver Kaut; Attila Kovacs; Thorsten Okulla; Horst Urbach; Thomas Klockgether
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Blood pressure     Volume:  19     ISSN:  1651-1999     ISO Abbreviation:  Blood Press.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-05     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  England    
Other Details:
Languages:  eng     Pagination:  267-9     Citation Subset:  IM    
Department of Neurology, University of Bonn, Bonn, Germany.
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MeSH Terms
Blood Pressure / physiology
Blood Pressure Monitoring, Ambulatory
Circadian Rhythm / physiology*
Hypertensive Encephalopathy / physiopathology*
Leukoencephalopathy, Progressive Multifocal / physiopathology*
Middle Aged
Posterior Leukoencephalopathy Syndrome / physiopathology*

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