Document Detail

Reversible lactose malabsorption and intolerance in Graves' disease.
MedLine Citation:
PMID:  1893649     Owner:  NLM     Status:  MEDLINE    
Ten patients with untreated Graves' disease underwent tests to determine lactose absorption, liquid gastric emptying, and oral cecal transit time. To determine the influence of thyroid hormone status on lactose absorption, eight of these same patients had repeat studies when rendered euthyroid. Two of these eight patients also underwent studies while transiently hypothyroid. Motility studies were also evaluated in a group of 11 control subjects. Lactose malabsorption occurred in nine patients with Graves' disease. In seven patients who repeated these studies, lactose malabsorption normalized in three, symptoms induced by lactose improved in two and were unchanged in two. However, these latter two patients appeared to have improved symptoms in the transient hypothyroid state. Liquid gastric emptying was significantly faster in untreated patients than controls and treated self-same patients. Transit time was significantly faster in untreated patients than when they were rendered euthyroid. There may be a relationship between altered lactose absorption states and changes in intestinal motility in patients with Graves' disease.
A Szilagyi; S Lerman; R G Barr; J Stern; A Colacone; S McMullan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and investigative medicine. Médecine clinique et experimentale     Volume:  14     ISSN:  0147-958X     ISO Abbreviation:  Clin Invest Med     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-10-24     Completed Date:  1991-10-24     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7804071     Medline TA:  Clin Invest Med     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  188-97     Citation Subset:  IM    
Department of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec.
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MeSH Terms
Gastric Emptying
Gastrointestinal Motility
Graves Disease / complications*,  drug therapy,  physiopathology
Lactose Intolerance / etiology*
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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