| Reversible lactic acidosis associated with repeated intravenous infusions of sorbitol and ethanol. | |
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MedLine Citation:
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PMID: 22069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infusions of fructose or sorbitol are used commonly in parenteral nutrition and may cause lactic acidosis. A case is reported in whom blood lactate concentration was monitored frequently over a 5-day period during intravenous feeding with a sorbitol-ethanol-amino acid mixture. During the first five infusions blood lactate rose only moderately, but with the final infusion lactate rose to 11-1 mmol/l and the patient had a severe metabolic acidosis. In retrospect the patient had shown deterioration in renal and hepatic function tests during the preceding 24 hr. On terminating the infusions the blood lactate concentration fell rapidly. It is suggested that great care should be exercised when using such infusions in ill patients and acid base status and renal and hepatic function should be monitored frequently. |
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Authors:
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G F Batstone; K G Alberti; A K Dewar |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Postgraduate medical journal Volume: 53 ISSN: 0032-5473 ISO Abbreviation: Postgrad Med J Publication Date: 1977 Sep |
Date Detail:
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Created Date: 1978-01-27 Completed Date: 1978-01-27 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0234135 Medline TA: Postgrad Med J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 567-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis
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chemically induced* Aged Ethanol / adverse effects* Humans Hydrogen-Ion Concentration Lactates / blood Male Parenteral Nutrition / adverse effects* Sorbitol / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 50-70-4/Sorbitol; 64-17-5/Ethanol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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