Document Detail


Reversible intracerebral pathologic entities mediated by vascular autoregulatory dysfunction.
MedLine Citation:
PMID:  9536483     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several cerebral pathologic processes thought to result from derangements in vascular autoregulatory mechanisms show reversible abnormalities on computed tomographic and magnetic resonance images. The hypertensive encephalopathies are characterized by intracranial abnormalities due to subacutely elevated blood pressure; these entities include hypertensive encephalopathy, preeclampsia and eclampsia, and cyclosporine toxicity. Imaging studies reveal symmetric confluent lesions with mild mass effect and patchy enhancement centered in the immediate subcortical white matter of the occipital lobes. The uremic encephalopathies are characterized by intracranial abnormalities due to an elevated level of blood urea nitrogen; these entities include uremia and glomerulonephritis, hemolytic-uremic syndrome, and thrombotic thrombocytopenic purpura. Imaging studies reveal multiple areas of symmetric edema in the basal ganglia; in severe cases, focal infarcts with or without hemorrhage can be seen. As radiologists become more familiar with these entities, cases can be recognized earlier in the disease process, allowing more timely initiation of appropriate therapy.
Authors:
J D Port; N J Beauchamp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiographics : a review publication of the Radiological Society of North America, Inc     Volume:  18     ISSN:  0271-5333     ISO Abbreviation:  Radiographics     Publication Date:    1998 Mar-Apr
Date Detail:
Created Date:  1998-05-14     Completed Date:  1998-05-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8302501     Medline TA:  Radiographics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  353-67     Citation Subset:  IM    
Affiliation:
Russell H. Morgan Department of Radiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / pathology,  radiography
Brain Diseases / diagnosis*,  etiology,  physiopathology,  radiography
Brain Diseases, Metabolic / diagnosis,  etiology,  pathology,  radiography
Cerebrovascular Circulation
Child
Child, Preschool
Cyclosporine / adverse effects
Eclampsia / complications
Female
Homeostasis
Humans
Hypertension / chemically induced,  complications*
Magnetic Resonance Imaging
Male
Middle Aged
Pre-Eclampsia / complications
Pregnancy
Tomography, X-Ray Computed
Uremia / complications
Chemical
Reg. No./Substance:
59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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