| Reversible inhibition by human serum lipoproteins of cell proliferation. | |
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MedLine Citation:
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PMID: 6215416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Normal human serum or plasma was studied for the presence of inhibitors of cell proliferation by assaying inhibition of incorporation of labeled thymidine into acid-insoluble fraction using human FL cells. Lipoprotein fraction obtained by gel filtration through Sepharose 4B and by KBr density gradient centrifugation was found to play a major part of the inhibitory activity of the serum. It was also shown that the inhibitory activity resides in low-density lipoprotein (LDL). The addition of the lipoprotein fraction to growing FL cells caused an early decrease in the transport of uridine and thymidine across the membrane. This change in the permeability of membrane was followed by the preferential inhibition of DNA synthesis and a reduction in the percentage of mitotic cells in the cell population. The inhibition of the growth was reversible and was observed in various types of cells irrespective of species. |
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Authors:
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F Ito; Y Takii; J Suzuki; Y Masamune |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cellular physiology Volume: 113 ISSN: 0021-9541 ISO Abbreviation: J. Cell. Physiol. Publication Date: 1982 Oct |
Date Detail:
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Created Date: 1982-12-21 Completed Date: 1982-12-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0050222 Medline TA: J Cell Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / drug effects Cell Division / drug effects* Cells, Cultured DNA Replication / drug effects Growth Inhibitors* Humans Lipoproteins / blood, pharmacology* Mice |
| Chemical | |
Reg. No./Substance:
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0/Growth Inhibitors; 0/Lipoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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