Document Detail

Reversible inhibition by human serum lipoproteins of cell proliferation.
MedLine Citation:
PMID:  6215416     Owner:  NLM     Status:  MEDLINE    
Normal human serum or plasma was studied for the presence of inhibitors of cell proliferation by assaying inhibition of incorporation of labeled thymidine into acid-insoluble fraction using human FL cells. Lipoprotein fraction obtained by gel filtration through Sepharose 4B and by KBr density gradient centrifugation was found to play a major part of the inhibitory activity of the serum. It was also shown that the inhibitory activity resides in low-density lipoprotein (LDL). The addition of the lipoprotein fraction to growing FL cells caused an early decrease in the transport of uridine and thymidine across the membrane. This change in the permeability of membrane was followed by the preferential inhibition of DNA synthesis and a reduction in the percentage of mitotic cells in the cell population. The inhibition of the growth was reversible and was observed in various types of cells irrespective of species.
F Ito; Y Takii; J Suzuki; Y Masamune
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cellular physiology     Volume:  113     ISSN:  0021-9541     ISO Abbreviation:  J. Cell. Physiol.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1982-12-21     Completed Date:  1982-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0050222     Medline TA:  J Cell Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
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MeSH Terms
Biological Transport / drug effects
Cell Division / drug effects*
Cells, Cultured
DNA Replication / drug effects
Growth Inhibitors*
Lipoproteins / blood,  pharmacology*
Reg. No./Substance:
0/Growth Inhibitors; 0/Lipoproteins

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