Document Detail

Reversible hypercholesterolaemia produced by cholesterol-free fish meal protein diets.
MedLine Citation:
PMID:  6686779     Owner:  NLM     Status:  MEDLINE    
Groups of rabbits were fed isonitrogenous diets containing 30% soya, milk or whitefish meal protein and at least 130 g/kg of added fat for 1 year. Mean serum cholesterol values in fish meal animals (13.4 +/- 2.4 mmol/l) were substantially greater than for soya (3.0 +/- 0.2 mmol/l) or milk (4.6 +/- 0.7 mmol/l). Fish meal rabbits developed extensive aortic atherosclerosis (c. 70% surface involvement) which histologically showed both fibrous and foam cell intimal thickening and destruction and calcification of medial elastic tissue. In a second experiment fish meal was given with either saturated (coconut oil) or unsaturated (maize oil) fat. A similar degree of hypercholesterolaemia developed in each group and was rapidly reversed when a soya protein-low fat diet was substituted. This model may therefore be of value in studies of the progression and regression of experimental atherosclerosis.
N J Goulding; M J Gibney; T G Taylor; P J Gallagher
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Atherosclerosis     Volume:  49     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-02-28     Completed Date:  1984-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  127-37     Citation Subset:  IM    
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MeSH Terms
Aorta / pathology
Arteriosclerosis / chemically induced,  pathology
Carotid Arteries / pathology
Diet, Atherogenic
Dietary Fats / adverse effects
Fish Products / adverse effects*
Hypercholesterolemia / chemically induced*
Milk / adverse effects
Soybeans / adverse effects
Reg. No./Substance:
0/Dietary Fats

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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