| Reversible hearing impairment: delayed complication of murine typhus or adverse reaction to azithromycin? | |
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MedLine Citation:
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PMID: 20110389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Delayed and reversible hearing loss occurred in a 55-year-old male patient with murine typhus infection. The patient had the initial symptoms of headache, fever and chills, followed by the occurrence of bilateral hearing loss on day 9 from fever onset. Murine typhus was diagnosed with a high IgM titre by indirect immunofluorescence assay. After treatment with azithromycin and prednisolone, the fever and other symptoms subsided gradually and bilateral hearing loss improved 3 weeks later. Though an adverse reaction to azithromycin could not be ruled out, delayed onset of hearing loss was more likely a complication of murine typhus, mainly because the hearing loss did not occur during the azithromycin usage period. Although hearing loss due to murine typhus is rare, clinicians should be alert to the existence of such a delayed complication. |
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Authors:
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Shang-Yi Lin; Ya-Ling Wang; Hsiu-Fen Lin; Tun-Chieh Chen; Yen-Hsu Chen; Po-Liang Lu |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-01-28 |
Journal Detail:
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Title: Journal of medical microbiology Volume: 59 ISSN: 1473-5644 ISO Abbreviation: J. Med. Microbiol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-15 Completed Date: 2010-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0224131 Medline TA: J Med Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 602-6 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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adverse effects*,
therapeutic use* Anti-Inflammatory Agents / therapeutic use Antibodies, Bacterial / blood Azithromycin / adverse effects*, therapeutic use* Fluorescent Antibody Technique, Indirect Hearing Loss / chemically induced, etiology* Humans Immunoglobulin M / blood Male Middle Aged Prednisolone / therapeutic use Typhus, Endemic Flea-Borne / complications*, diagnosis, drug therapy*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Anti-Inflammatory Agents; 0/Antibodies, Bacterial; 0/Immunoglobulin M; 50-24-8/Prednisolone; 83905-01-5/Azithromycin |
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