Document Detail

Reversible hearing impairment: delayed complication of murine typhus or adverse reaction to azithromycin?
MedLine Citation:
PMID:  20110389     Owner:  NLM     Status:  MEDLINE    
Delayed and reversible hearing loss occurred in a 55-year-old male patient with murine typhus infection. The patient had the initial symptoms of headache, fever and chills, followed by the occurrence of bilateral hearing loss on day 9 from fever onset. Murine typhus was diagnosed with a high IgM titre by indirect immunofluorescence assay. After treatment with azithromycin and prednisolone, the fever and other symptoms subsided gradually and bilateral hearing loss improved 3 weeks later. Though an adverse reaction to azithromycin could not be ruled out, delayed onset of hearing loss was more likely a complication of murine typhus, mainly because the hearing loss did not occur during the azithromycin usage period. Although hearing loss due to murine typhus is rare, clinicians should be alert to the existence of such a delayed complication.
Shang-Yi Lin; Ya-Ling Wang; Hsiu-Fen Lin; Tun-Chieh Chen; Yen-Hsu Chen; Po-Liang Lu
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-01-28
Journal Detail:
Title:  Journal of medical microbiology     Volume:  59     ISSN:  1473-5644     ISO Abbreviation:  J. Med. Microbiol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-15     Completed Date:  2010-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0224131     Medline TA:  J Med Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  602-6     Citation Subset:  IM    
Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC.
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MeSH Terms
Anti-Bacterial Agents / adverse effects*,  therapeutic use*
Anti-Inflammatory Agents / therapeutic use
Antibodies, Bacterial / blood
Azithromycin / adverse effects*,  therapeutic use*
Fluorescent Antibody Technique, Indirect
Hearing Loss / chemically induced,  etiology*
Immunoglobulin M / blood
Middle Aged
Prednisolone / therapeutic use
Typhus, Endemic Flea-Borne / complications*,  diagnosis,  drug therapy*,  pathology
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Inflammatory Agents; 0/Antibodies, Bacterial; 0/Immunoglobulin M; 50-24-8/Prednisolone; 83905-01-5/Azithromycin

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