Document Detail

Reversible graft versus host reaction as cause of erythrophagic splenomegaly in a child?
MedLine Citation:
PMID:  21093     Owner:  NLM     Status:  MEDLINE    
The case history of a 9 months old infant with hepatosplenomegaly, pancytopnaenia and disturbances of clotting and cellular immune reactivity is reported. The spleen was removed and showed striking erythrophagocytosis by proliferating histiocytes, typical of "familial erythrophagocytic reticulosis" (Farquhar). A graft-versus-host reaction is discussed as a possible underlying cause. The favourable clinical course and full recovery point to an interrelation with primary hypersplenism.
J D Beck; J E Weinig; H K Müller-Hermelink; E M Lemmel
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of pediatrics     Volume:  126     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1977-12-29     Completed Date:  1977-12-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  175-84     Citation Subset:  IM    
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MeSH Terms
Blood Coagulation Disorders / etiology
Graft vs Host Reaction*
Hepatomegaly / etiology
Immunity, Cellular
Pancytopenia / etiology*
Splenomegaly / etiology*

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