Document Detail

Reversible flow of cholesteryl ester between high-density lipoproteins and triacylglycerol-rich particles is modulated by the fatty acid composition and concentration of triacylglycerols.
MedLine Citation:
PMID:  21140099     Owner:  NLM     Status:  In-Process    
We determined the influence of fasting (FAST) and feeding (FED) on cholesteryl ester (CE) flow between high-density lipoproteins (HDL) and plasma apoB-lipoprotein and triacylglycerol (TG)-rich emulsions (EM) prepared with TG-fatty acids (FAs). TG-FAs of varying chain lengths and degrees of unsaturation were tested in the presence of a plasma fraction at d > 1.21 g/mL as the source of CE transfer protein. The transfer of CE from HDL to FED was greater than to FAST TG-rich acceptor lipoproteins, 18% and 14%, respectively. However, percent CE transfer from HDL to apoB-containing lipoproteins was similar for FED and FAST HDL. The CE transfer from HDL to EM depended on the EM TG-FA chain length. Furthermore, the chain length of the monounsaturated TG-containing EM showed a significant positive correlation of the CE transfer from HDL to EM (r = 0.81, P < 0.0001) and a negative correlation from EM to HDL (r = -041, P = 0.0088). Regarding the degree of EM TG-FAs unsaturation, among EMs containing C18, the CE transfer was lower from HDL to C18:2 compared to C18:1 and C18:3, 17.7%, 20.7%, and 20%, respectively. However, the CE transfer from EMs to HDL was higher to C18:2 than to C18:1 and C18:3, 83.7%, 51.2%, and 46.3%, respectively. Thus, the EM FA composition was found to be the rate-limiting factor regulating the transfer of CE from HDL. Consequently, the net transfer of CE between HDL and TG-rich particles depends on the specific arrangement of the TG acyl chains in the lipoprotein particle core.
P M Cazita; L N Castilho; M D T Carvalho; A C Sesso; H C F Oliveira; E C R Quintão
Related Documents :
1486659 - Molecular weight determination of methyl esters of mycolic acids using thermospray mass...
9351909 - Reversible formation of fatty acid esters of budesonide, an antiasthma glucocorticoid, ...
3133959 - High pressure liquid chromatography methods for separation of omega- and (omega-1)-hydr...
8309999 - Metabolically convertible lipophilic derivatives of ph-sensitive amphipathic photosensi...
11537439 - Enzymic synthesis of indole-3-acetyl-1-o-beta-d-glucose. ii. metabolic characteristics ...
5802639 - Relative rates of hydrolysis by rat pancreatic lipase of esters of c2-c18 fatty acids w...
16272149 - Starvation-induced cleavage of the trna anticodon loop in tetrahymena thermophila.
16332779 - Exogenous isoleucine and fatty acid shortening ensure the high content of anteiso-c15:0...
16780419 - Differential expression of a c-terminal splice variant of phosphatidylinositol transfer...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-03
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  43     ISSN:  1414-431X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  1135-42     Citation Subset:  IM    
Universidade de São Paulo, SP, Brasil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Possible in vivo mechanisms involved in photodynamic therapy using tetrapyrrolic macrocycles.
Next Document:  Spectral and symbolic analysis of the effect of gender and postural change on cardiac autonomic modu...