Document Detail

Reversible findings of restricted diffusion in 5-fluorouracil neurotoxicity.
MedLine Citation:
PMID:  16884425     Owner:  NLM     Status:  MEDLINE    
A 35-year-old woman presented with neurotoxicity correlated to an i.v. regimen of 5-fluorouracil as episodes of acute confusional state and abnormalities of symmetrically restricted diffusion in the periventricular white matter and corpus callosum. On discontinuing the medication, the areas of severely restricted diffusion had entirely resolved, with minimal residual T2 signal abnormality. In this case, immediate discontinuation of the chemotherapeutic agent apparently reversed the patient's symptoms and findings on MRI. The scant information available in the published literature regarding this phenomenon is reviewed with regard to 5-fluorouracil.
L T Lucato; A M McKinney; J Short; M Teksam; C L Truwit
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Australasian radiology     Volume:  50     ISSN:  0004-8461     ISO Abbreviation:  Australas Radiol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-03     Completed Date:  2006-10-13     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047441     Medline TA:  Australas Radiol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  364-8     Citation Subset:  IM    
Department of Radiology, University of Minnesota Medical School and Hennepin County Medical Center, Minneapolis, MN 55415, USA.
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MeSH Terms
Antimetabolites, Antineoplastic / administration & dosage,  adverse effects*,  therapeutic use
Anus Neoplasms / drug therapy
Carcinoma, Squamous Cell / drug therapy
Corpus Callosum
Fluorouracil / administration & dosage,  adverse effects*,  therapeutic use
Infusions, Intravenous
Magnetic Resonance Imaging / methods*
Neurotoxicity Syndromes / diagnosis*
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 51-21-8/Fluorouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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