| Reversible fetal renal failure after maternal treatment with Candesartan: a case report. | |
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MedLine Citation:
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PMID: 20132879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite data suggesting that angiotensin-receptor blockers (ARBs) are associated with increased risk to the fetus, there has been an increasing exposure of ARBs in pregnancy. We report a case report regarding a woman, who accidentally was treated with Candesartan during the first 22 weeks of pregnancy. At 22 weeks of gestation the fetal kidneys were oedematous with very little amniotic fluid. The prognosis for the fetus was considered poor. Five weeks after discontinuation of Candesartan normal quantities of amnionic fluid and a visible fetal bladder was registered. After delivery at week 31, creatinine clearance, diuresis and urine examination of the neonate were within normal limits. Ultrasound examinations of the kidneys showed bilaterally marked calices, small cysts and parenchymal increased echogenety at 1 week with complete sonographic normalization at 6 weeks. However, experimental studies raise the question of potential long-term adverse effects, including renal dysfunction and arterial hypertension in adulthood. |
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Authors:
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Peter Scott Munk; Philip von Brandis; Alf Inge Larsen |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-02-02 |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 29 ISSN: 1873-1708 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-16 Completed Date: 2010-07-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 381-2 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Cardiology, Stavanger University Hospital, Stavanger, Norway. munk@lyse.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniotic Fluid Antihypertensive Agents / adverse effects* Benzimidazoles / adverse effects* Creatinine Female Fetus / physiopathology Humans Hypertension / chemically induced Infant, Newborn Kidney / physiopathology Kidney Failure / chemically induced*, physiopathology Pregnancy Tetrazoles / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Benzimidazoles; 0/Tetrazoles; 139481-59-7/candesartan; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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