Document Detail


Reversible fetal renal failure after maternal treatment with Candesartan: a case report.
MedLine Citation:
PMID:  20132879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite data suggesting that angiotensin-receptor blockers (ARBs) are associated with increased risk to the fetus, there has been an increasing exposure of ARBs in pregnancy. We report a case report regarding a woman, who accidentally was treated with Candesartan during the first 22 weeks of pregnancy. At 22 weeks of gestation the fetal kidneys were oedematous with very little amniotic fluid. The prognosis for the fetus was considered poor. Five weeks after discontinuation of Candesartan normal quantities of amnionic fluid and a visible fetal bladder was registered. After delivery at week 31, creatinine clearance, diuresis and urine examination of the neonate were within normal limits. Ultrasound examinations of the kidneys showed bilaterally marked calices, small cysts and parenchymal increased echogenety at 1 week with complete sonographic normalization at 6 weeks. However, experimental studies raise the question of potential long-term adverse effects, including renal dysfunction and arterial hypertension in adulthood.
Authors:
Peter Scott Munk; Philip von Brandis; Alf Inge Larsen
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-02-02
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  29     ISSN:  1873-1708     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-16     Completed Date:  2010-07-13     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  381-2     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Cardiology, Stavanger University Hospital, Stavanger, Norway. munk@lyse.net
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MeSH Terms
Descriptor/Qualifier:
Adult
Amniotic Fluid
Antihypertensive Agents / adverse effects*
Benzimidazoles / adverse effects*
Creatinine
Female
Fetus / physiopathology
Humans
Hypertension / chemically induced
Infant, Newborn
Kidney / physiopathology
Pregnancy
Renal Insufficiency / chemically induced*,  physiopathology
Tetrazoles / adverse effects*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Benzimidazoles; 0/Tetrazoles; 60-27-5/Creatinine; S8Q36MD2XX/candesartan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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