Document Detail

Reversible fetal hydrops associated with indomethacin use.
MedLine Citation:
PMID:  11770593     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ductus arteriosus constriction is a known complication of exposure to indomethacin in utero. Nonimmune hydrops associated with indomethacin use has been reported in only six cases, all twins over 32 weeks' gestation. CASE: We present a case of fetal hydrops associated with tricuspid regurgitation and ductal constriction developing within 30 hours of instituting indomethacin tocolysis in a 28-week singleton gestation. Discontinuation of indomethacin resulted in partial resolution of these findings 72 hours later. A normal infant was delivered subsequently. CONCLUSION: Ultrasonographic screening for signs of constriction of the ductus arteriosus should be done within 48 hours of instituting indomethacin therapy at any gestational age.
L Pratt; J Digiosia; J N Swenson; B Trampe; C B Martin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  90     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1997 Oct 
Date Detail:
Created Date:  2001-12-27     Completed Date:  2002-01-14     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  676-8     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Wisconsin-Madison, 53715, USA.
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MeSH Terms
Ductus Arteriosus / drug effects
Hydrops Fetalis / chemically induced*,  ultrasonography
Indomethacin / adverse effects*
Time Factors
Tocolytic Agents / adverse effects*
Tricuspid Valve Insufficiency / chemically induced
Ultrasonography, Prenatal
Reg. No./Substance:
0/Tocolytic Agents; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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