| Reversible encephalopathy after cryopreserved peripheral blood stem cell infusion. | |
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MedLine Citation:
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PMID: 7908165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report two patients who experienced severe reversible encephalopathy following infusion of peripheral blood stem cells cryopreserved in 10% dimethylsulfoxide (DMSO). In one patient, reduction of DMSO level with plasmapheresis resulted in marked improvement in encephalopathy. Infusion of large volumes of cryopreserved stem cells may result in a significant toxic reaction. Plasmapheresis may be a treatment option for patients with significant toxicity related to DMSO. |
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Authors:
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M Dhodapkar; S L Goldberg; A Tefferi; M A Gertz |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of hematology Volume: 45 ISSN: 0361-8609 ISO Abbreviation: Am. J. Hematol. Publication Date: 1994 Feb |
Date Detail:
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Created Date: 1994-04-26 Completed Date: 1994-04-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 187-8 Citation Subset: IM |
Affiliation:
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Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain Diseases
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etiology*,
therapy Cell Transplantation / adverse effects* Cryopreservation Dimethyl Sulfoxide / pharmacology Hematopoietic Stem Cell Transplantation* Hematopoietic Stem Cells / drug effects Humans Male Middle Aged Plasmapheresis |
| Chemical | |
Reg. No./Substance:
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67-68-5/Dimethyl Sulfoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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