| Reversible decrease of portal venous flow in cirrhotic patients: a positive side effect of sorafenib. | |
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MedLine Citation:
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PMID: 21340026 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Portal hypertension, the most important complication with cirrhosis of the liver, is a serious disease. Sorafenib, a tyrosine kinase inhibitor is validated in advanced hepatocellular carcinoma. Because angiogenesis is a pathological hallmark of portal hypertension, the goal of our study was to determine the effect of sorafenib on portal venous flow and portosystemic collateral circulation in patients receiving sorafenib therapy for advanced hepatocellular carcinoma. Porto-collateral circulations were evaluated using a magnetic resonance technique prior sorafenib therapy, and at day 30. All patients under sorafenib therapy had a decrease in portal venous flow of at least 36%. In contrast, no specific change was observed in the azygos vein or the abdominal aorta. No portal venous flow modification was observed in the control group. Sorafenib is the first anti-angiogenic therapy to demonstrate a beneficial and reversible decrease of portal venous flow among cirrhotic patients. |
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Authors:
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Romain Coriat; Hervé Gouya; Olivier Mir; Stanislas Ropert; Olivier Vignaux; Stanislas Chaussade; Philippe Sogni; Stanislas Pol; Benoit Blanchet; Paul Legmann; François Goldwasser |
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Publication Detail:
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Type: Journal Article Date: 2011-02-14 |
Journal Detail:
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Title: PloS one Volume: 6 ISSN: 1932-6203 ISO Abbreviation: PLoS ONE Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101285081 Medline TA: PLoS One Country: United States |
Other Details:
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Languages: eng Pagination: e16978 Citation Subset: IM |
Affiliation:
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Center for Research on Angiogenesis Inhibitors (CERIA), Hôpital Cochin, AP-HP, Paris, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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