| Reversible covalent chemistry in drug delivery. | |
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MedLine Citation:
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PMID: 16472224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The targeting of drugs specifically to their sites of action is an important strategy for increasing drug efficacy. Chemists have come up with many elegant schemes that aim to convert drugs into magic bullets. This review focuses on the chemistry that underlies these schemes, with particular emphasis on two types of cleavable covalent bonds that are frequently used to link drugs to their various carriers: disulfide bonds and hydrazone bonds. These linkages have been used to release drugs under specific conditions; in the case of disulfides, cleavage is triggered by the mildly reducing environment found in intracellular fluids, and in the case of hydrazones, the acidic conditions that prevail in endosomes cause release of the drug. The applications of these chemistries in drug delivery are reviewed. |
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Authors:
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Kevin R West; Sijbren Otto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current drug discovery technologies Volume: 2 ISSN: 1570-1638 ISO Abbreviation: Curr Drug Discov Technol Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2006-02-13 Completed Date: 2006-03-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101157212 Medline TA: Curr Drug Discov Technol Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 123-60 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemistry, Pharmaceutical Disulfides / chemistry* Drug Delivery Systems* Humans Hydrazones / chemistry* Pharmaceutical Preparations / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Disulfides; 0/Hydrazones; 0/Pharmaceutical Preparations |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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