Document Detail


Reversible covalent chemistry in drug delivery.
MedLine Citation:
PMID:  16472224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The targeting of drugs specifically to their sites of action is an important strategy for increasing drug efficacy. Chemists have come up with many elegant schemes that aim to convert drugs into magic bullets. This review focuses on the chemistry that underlies these schemes, with particular emphasis on two types of cleavable covalent bonds that are frequently used to link drugs to their various carriers: disulfide bonds and hydrazone bonds. These linkages have been used to release drugs under specific conditions; in the case of disulfides, cleavage is triggered by the mildly reducing environment found in intracellular fluids, and in the case of hydrazones, the acidic conditions that prevail in endosomes cause release of the drug. The applications of these chemistries in drug delivery are reviewed.
Authors:
Kevin R West; Sijbren Otto
Related Documents :
9282464 - A totally implantable drug delivery system for local therapy of the middle and inner ear.
9552494 - Use of local drug delivery for treating intracoronary thrombus and thrombus-containing ...
20430314 - Transdermal delivery of sumatriptan for the treatment of acute migraine.
20132094 - Distinctive features of "chronotherapeutic" and "pulsatile" drug delivery systems negat...
12721394 - Reactive metabolites and adverse drug reactions: clinical considerations.
8094094 - Synthesis and pet studies of fluorine-18-bmy 14802: a potential antipsychotic drug.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current drug discovery technologies     Volume:  2     ISSN:  1570-1638     ISO Abbreviation:  Curr Drug Discov Technol     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2006-02-13     Completed Date:  2006-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101157212     Medline TA:  Curr Drug Discov Technol     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  123-60     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Chemistry, Pharmaceutical
Disulfides / chemistry*
Drug Delivery Systems*
Humans
Hydrazones / chemistry*
Pharmaceutical Preparations / administration & dosage
Chemical
Reg. No./Substance:
0/Disulfides; 0/Hydrazones; 0/Pharmaceutical Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The isolated perfused rat kidney model: a useful tool for drug discovery and development.
Next Document:  Reverse pharmacognosy: application of selnergy, a new tool for lead discovery. The example of epsilo...