Document Detail

Reversible changes in rat spermatogenesis induced by an antifertility substance (Gossypol). A histochemical report.
MedLine Citation:
PMID:  2420139     Owner:  NLM     Status:  MEDLINE    
Male rats received Gossypol 30 mg/kg body mass daily through intubation for 30 and 60 d. The testes were processed for histological and histochemical lipid staining, thiamine pyrophosphatase (TPPase), and alpha-glycerophosphate dehydrogenase (alpha-GPDH)--examinations. Gossypol induced effects were: various types of deformations of elongated spermatids, and their loss of orientation towards the lamina propria during the maturation phase; displacement of germ cells and occasionally also of Sertoli cells towards the lumen of the seminiferous tubule in form of a "puff". TPPase was observed in the supranuclear region of dislocated round spermatids and pachytene spermatocytes. alpha-GPDH was observed in the split pieces of mid- and tail pieces of elongated spermatids enclosed in the "puff". The induced effects were reversible.
S G Haider; D Passia; K Q Chen; W E Stumpf
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta histochemica     Volume:  77     ISSN:  0065-1281     ISO Abbreviation:  Acta Histochem.     Publication Date:  1985  
Date Detail:
Created Date:  1986-04-09     Completed Date:  1986-04-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370320     Medline TA:  Acta Histochem     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  185-91     Citation Subset:  IM    
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MeSH Terms
Cytoplasmic Granules / analysis
Glycerolphosphate Dehydrogenase / metabolism
Gossypol / pharmacology*
Lipids / analysis
Rats, Inbred Strains
Seminiferous Tubules / analysis
Sertoli Cells / analysis
Spermatogenesis / drug effects*
Staining and Labeling / methods
Testis / analysis*,  drug effects,  pathology
Thiamine Pyrophosphatase / metabolism
Reg. No./Substance:
0/Lipids; 303-45-7/Gossypol; EC 1.1.-/Glycerolphosphate Dehydrogenase; EC 3.6.1.-/Thiamine Pyrophosphatase

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