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Reversible cerebral vasoconstriction syndrome possibly induced by etoricoxib.
MedLine Citation:
PMID:  25229174     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Etoricoxib is a newer cyclooxygenase (COX)-2 inhibitor anti-inflammatory drug with a favorable safety profile. However, several randomized trials have provided evidence of an increased risk for acute myocardial infarction associated with the use of COX-2 inhibitors. Fewer data are available concerning the risk for ischemic stroke associated with COX-2 inhibitors. Although sporadic classes of drug-induced reversible cerebral vasoconstriction syndrome (RCVS) have been reported, this was not the case for etoricoxib. We report a patient who developed thunderclap headache, reversible cerebral arterial vasoconstriction, high blood pressure, and ischemic stroke (ie, RCVS) with recent exposure to etoricoxib. Although the association is hypothetical, the authors suggest consideration of RCVS in hypertensive patients presenting with headache, focal deficits, and evidence of cerebral ischemia during COX-2 inhibitors use.
Authors:
Carlo Dallocchio; Carla Arbasino; Giuseppina Borutti; Giada Gola; Maria Grazia Egitto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical neuropharmacology     Volume:  37     ISSN:  1537-162X     ISO Abbreviation:  Clin Neuropharmacol     Publication Date:    2014 Sep-Oct
Date Detail:
Created Date:  2014-09-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7607910     Medline TA:  Clin Neuropharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  154-7     Citation Subset:  IM    
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