| Reversible cardiomyopathy caused by administration of interferon alpha. | |
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MedLine Citation:
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PMID: 16265343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A 56-year-old man with normal cardiac function received treatment with interferon alpha-2b for malignant melanoma. Eight months after the initiation of therapy he developed fatigue and dyspnea on exertion. Two months later, he was admitted to hospital with ORTHOPNEA, worsening dyspnea and cough. Physical examination findings were consistent with congestive heart failure. Laboratory studies were notable for hypothyroidism. Echocardiography revealed severe, global left-ventricular dysfunction. INVESTIGATIONS: Echocardiogram, electrocardiogram, serum chemistries, coronary angiography, right-heart and left-heart catheterization and endomyocardial biopsy. DIAGNOSIS: Interferon alpha-2b-induced cardiomyopathy. MANAGEMENT: Intravenous dobutamine and dopamine for cardiogenic shock and discontinuation of interferon alpha-2b. |
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Authors:
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Aarif Y Khakoo; Marc K Halushka; J Eduardo Rame; E Rene Rodriguez; Edward K Kasper; Daniel P Judge |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nature clinical practice. Cardiovascular medicine Volume: 2 ISSN: 1743-4297 ISO Abbreviation: - Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-11-02 Completed Date: 2005-12-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101226507 Medline TA: Nat Clin Pract Cardiovasc Med Country: England |
Other Details:
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Languages: eng Pagination: 53-7 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Johns Hopkins University, Baltimore, MD 21287, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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adverse effects* Cardiomyopathies / chemically induced* Follow-Up Studies Head and Neck Neoplasms / drug therapy, surgery Heart Failure / chemically induced Humans Interferon Alfa-2b / adverse effects* Male Melanoma / drug therapy, surgery Middle Aged Myocarditis / chemically induced Skin Neoplasms / drug therapy, surgery Ventricular Dysfunction, Left / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 99210-65-8/Interferon Alfa-2b |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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