Document Detail

Reversible bilateral blepharoptosis following oxaliplatin infusion: a case report and literature review.
MedLine Citation:
PMID:  24501793     Owner:  NLM     Status:  In-Process    
Oxaliplatin, a platinum analogue employed in the treatment of colorectal cancer and various other neoplasms, is characterized by a broad range of adverse events. Peripheral neuropathy is probably the most peculiar and clinically relevant toxicity associated with its use and can be distinguished into two types: acute and chronic neurotoxicity.We report a case of acute reversible bilateral palpebral ptosis and dyspnea without bronchospasm or laryngospasm which occurred at the end of the third administration of adjuvant oxaliplatin by infusion for stage III colon cancer in a 54-year-old woman. Chlorphenamine and hydrocortisone were administered with fast resolution of dyspnea and slight improvement of ptosis. Complete resolution with no sequelae occurred in one hour. No further recurrence of blepharoptosis was described during the following days. The subsequent cycles were prescribed at reduced dosage without acute complications.
Giuseppe Fanetti; Laura A M Ferrari; Filippo Pietrantonio; Roberto Buzzoni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tumori     Volume:  99     ISSN:  2038-2529     ISO Abbreviation:  Tumori     Publication Date:    2013 Sep-Oct
Date Detail:
Created Date:  2014-02-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  e216-9     Citation Subset:  IM    
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