| Reversible association of the cytokines MIP-1 alpha and MIP-1 beta with the endothelia of the blood-brain barrier. | |
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MedLine Citation:
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PMID: 8852593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Macrophage inflammatory proteins (MIP)-1 alpha and -1 beta have been postulated to exert their pyrogenic effects by acting directly at sites within the brain. Such activity would require circulating MIP-1s to cross the blood-brain barrier (BBB). We examined the ability of the monomer and polymer of MIP-1 alpha and the polymer of MIP-1 beta radioactively labeled with 125iodine (I-MIP-1) to cross the BBB. These I-MIP-1s behaved very similarly to each other but in a manner not previously seen for other cytokines. The I-MIP-1s immediately associated to a high degree and in a reversible manner with the vascular space of the brain. This association did not increase over time nor was it self-inhibitable. These results make it unlikely that the MIP-1s are transported into the brain by saturable transport systems in the manner found for some of the other cytokines. Other mechanisms, such as interactions with brain endothelia, leakage into brain through extracellular pathways, and binding at circumventricular organs, are more likely to provide the mechanisms through which blood-borne MIP-1s affect the central nervous system. |
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Authors:
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W A Banks; A J Kastin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Neuroscience letters Volume: 205 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-12-16 Completed Date: 1996-12-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 202-6 Citation Subset: IM |
Affiliation:
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Veterans Affairs Medical Center and Tulane University School of Medicine, New Orleans, LA 70146, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / physiology Blood-Brain Barrier / physiology* Chemokine CCL4 Endothelium, Vascular / drug effects, metabolism Growth Inhibitors / pharmacokinetics* Injections, Intravenous Macrophage Inflammatory Proteins / pharmacokinetics* Male Mice Mice, Inbred ICR Recombinant Proteins / pharmacokinetics Regression Analysis |
| Chemical | |
Reg. No./Substance:
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0/Chemokine CCL4; 0/Growth Inhibitors; 0/Macrophage Inflammatory Proteins; 0/Recombinant Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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