| Reversible alterations in fatty acid profile of glycerophospholipids in rat heart muscle induced by repeated norepinephrine administration. | |
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MedLine Citation:
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PMID: 6824706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats were injected subcutaneously for 2 weeks with increasing amounts of norepinephrine. The lipid composition of the heart muscle was examined for nearly 2 months. The treatment caused major changes in fatty acyl chain composition of myocardial phosphatidylethanolamine and phosphatidylcholine. In these phospholipids, linoleic acid was decreased to about half of the control value but docosahexaenoic acid increased about 50% in phoshatidylethanolamine and more than doubled in phosphatidylcholine. Arachidonic acid content rose about 50% in phosphatidylcholine but was lowered in phosphatidylethanolamine. The cardiolipin fraction retained its high amount of linoleic acid and the fatty acid composition of the triacylglycerol was not altered, although the amount was significantly decreased. These changes reverted to control levels in 4-8 days after the final injection, although rebound behaviour was observed. An inverse relationship between arachidonic acid content of phosphatidylcholine and phosphatidylethanolamine was observed. |
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Authors:
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A Emilsson; S Gudbjarnason |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 750 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1983 Jan |
Date Detail:
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Created Date: 1983-04-15 Completed Date: 1983-04-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 1-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiolipins / metabolism Fatty Acids / metabolism* Heart / drug effects Kinetics Male Myocardium / metabolism* Norepinephrine / pharmacology* Organ Size / drug effects Phosphatidylcholines / metabolism Phosphatidylethanolamines / metabolism Phospholipids / metabolism* Rats Rats, Inbred Strains Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cardiolipins; 0/Fatty Acids; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Phospholipids; 0/Triglycerides; 51-41-2/Norepinephrine |
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