Document Detail

Reversible Symptomatic Myocarditis Induced by All-Trans Retinoic Acid Administration during Induction Treatment of Acute Promyelocytic Leukemia: Rare Cardiac Manifestation as a Retinoic Acid Syndrome.
MedLine Citation:
PMID:  21860725     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Treatment by All-trans retinoic acid (ATRA) followed by anthracycline-AraC chemotherapy has improved the outcome of acute promyelocytic leukemia. ATRA is usually well tolerated, but a few major side effects can be observed. Retinoic acid syndrome (RAS) often occurs during the induction chemotherapy of acute promyelocytic leukemia. A pericardial effusion is a common cardiac manifestation but myocarditis has been rarely documented. Here we reports a very rare case of fully recovered myocarditis as a result of RAS related to ATRA administration during induction treatment of acute promyelocytic leukemia which documented by echocardiographic evidence.
Seonghoon Choi; Hyeong-Su Kim; Chang-Soo Jung; Seong-Woong Jung; Yun-Ja Lee; Jin-Kyeong Rheu; Jung-Rae Jo; Nam-Ho Lee
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Publication Detail:
Type:  Journal Article     Date:  2011-06-30
Journal Detail:
Title:  Journal of cardiovascular ultrasound     Volume:  19     ISSN:  2005-9655     ISO Abbreviation:  J Cardiovasc Ultrasound     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-08-23     Completed Date:  2011-11-10     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101477138     Medline TA:  J Cardiovasc Ultrasound     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  95-8     Citation Subset:  -    
Division of Cardiology, Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
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