| Reversible Splenial Lesion Syndrome (RESLES): What's in a Name? | |
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MedLine Citation:
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PMID: 18681931 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: The presence of transient lesions involving the splenium of the corpus callosum (SCC) has been described in patients with encephalitis or encephalopathy of varied etiology. We have termed it RESLES (reversible splenial lesion syndrome). PURPOSE: To describe 3 additional patients (2 encephalitis, 1 hypoglycemia) and review the literature to define this syndrome, its etiology, presentation, prognosis, and possible pathophysiological mechanisms. METHODS: Search of the MEDLINE database from 1966 through 2007. English language article titles and abstracts were screened and the appropriate articles reviewed. Additional articles cited by original references were also reviewed. RESULTS: RESLES is caused by antiepileptic drug withdrawal, infection, high-altitude cerebral edema (HACE), or metabolic disorders (hypoglycemia and hypernatremia). Complete resolution after a variable lapse is the rule. Clinical presentation is nonspecific, without evidence of callosal disconnection syndromes. Neuroimaging shows a nonenhancing, round-shaped lesion centered in the SCC that disappears after a variable lapse. Diffusion studies reveal DW hypersignal with low ADC values, suggestive of cytotoxic edema. Only HACE-related cases and 1 patient with pregabalin withdrawal showed high ADC values, consistent with vasogenic edema. CONCLUSION: RESLES is a distinct clinicoradiological syndrome of varied etiology and benign course except in those patients with an underlying severe disorder. |
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Authors:
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Juan Carlos Garcia-Monco; Ines Escalza Cortina; Eva Ferreira; Amaia Martínez; Lara Ruiz; Alberto Cabrera; Marian Gomez Beldarrain |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 21 ISSN: 1552-6569 ISO Abbreviation: J Neuroimaging Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: United States |
Other Details:
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Languages: eng Pagination: e1-e14 Citation Subset: IM |
Copyright Information:
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Copyright © 2008 by the American Society of Neuroimaging. |
Affiliation:
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Servicio de Neurologia, Hospital de Galdacano, Vizcaya, Spain (JCG, IEC, EF, AM, LR, MGB); and Magnetic Resonance Unit, Osatek, Galdacano, Vizcaya, Spain (AC). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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