Document Detail

Reversible Fanconi syndrome in a pediatric patient on deferasirox.
MedLine Citation:
PMID:  21136524     Owner:  NLM     Status:  Publisher    
Deferasirox (Exjade®, Novartis) is a widely used oral iron chelator for the treatment of patients with iron overload due to chronic transfusion therapy for diseases such as β-thalassemia and sickle cell disease. Renal side effects of deferasirox are common and include non-progressive increases in serum creatinine, however, the effect of deferasirox on proximal tubule function is unclear. We report one pediatric patient with reversible Fanconi syndrome associated with long-term deferasirox therapy and one patient with mild proximal tubular dysfunction. Kidney and proximal tubular function should be periodically monitored in patients receiving deferasirox throughout their course of therapy. Pediatr Blood Cancer © 2010 Wiley-Liss, Inc.
Michelle N Rheault; Heather Bechtel; Joseph P Neglia; Clifford E Kashtan
Related Documents :
19729384 - Prospective comparison of the pneumatic cuff and manual compression methods in diagnosi...
6429444 - The ph of mitochondria of fibroblasts from a hyperornithinaemia, hyperammonaemia, homoc...
7694994 - Effects of erucic acid therapy on japanese patients with x-linked adrenoleukodystrophy.
19798574 - Prevalence of barrett's esophagus remains low in the korean population: nationwide cros...
18062114 - Does periodontal disease reflect atherosclerosis in continuous ambulatory peritoneal di...
12846064 - Severe childhood uveitis without overt arthritis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-6
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  -     ISSN:  1545-5017     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pediatrics, University of Minnesota Amplatz Children's Hospital, Minneapolis, Minnesota.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Patterns of mineral lick visitation by spider monkeys and howler monkeys in Amazonia: are licks perc...
Next Document:  Age- and task-dependent foraging gene expression in the bumblebee Bombus terrestris.