| Reversibility of tributyltin-chloride-induced protein synthesis inhibition after ATP recovery in HEL-30 cells. | |
| | |
MedLine Citation:
|
PMID: 2389259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of tributyltin chloride (TBT) on ATP levels and protein synthesis was investigated in a murine epidermal cell line (HEL-30). Five minutes after exposure to 10(-5) M TBT, cellular levels of ATP decreased by 57% and protein synthesis was significantly inhibited. The effect of ATP was stable up to 2 h incubation, whereas inhibition of protein synthesis increased with time of treatment. Partial (1 h) or complete (2 h) recovery of the two cell functions was observed when dithiothreitol (DTT) was added to the medium, 5 min after the damage and in the absence of TBT. The sequence of the observed effects suggests that TBT inhibition of protein synthesis is due to impairment of ATP production. |
| | |
Authors:
|
M Marinovich; B Viviani; C L Galli |
Related Documents
:
|
793989 - Mechanisms for the microbicidal activity of cationic proteins of human granulocytes. 12730959 - Effect of endothelin-1 on astrocytic protein content. 597269 - Effect of microtubular or translational inhibitors on general cell protein degradation.... 21077849 - Protein isoprenylation regulates osteogenic differentiation of mesenchymal stem cells: ... 14751229 - A novel inhibitor protein of n-myristoyltransferase from escherichia coli. 10997939 - The role of conjugation in hepatotoxicity of troglitazone in human and porcine hepatocy... 3351919 - Protein-ligand dynamics. a 96 picosecond simulation of a myoglobin-xenon complex. 12832219 - Detection of porcine endogenous retrovirus (perv) using highly specific antisera agains... 17993479 - The structure of isolated cardiac myosin thick filaments from cardiac myosin binding pr... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Toxicology letters Volume: 52 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 1990 Aug |
Date Detail:
|
Created Date: 1990-09-27 Completed Date: 1990-09-27 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 311-7 Citation Subset: IM |
Affiliation:
|
Institute of Pharmacological Sciences, University of Milan, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine Triphosphate
/
biosynthesis* Animals Cell Line / drug effects Dithiothreitol / pharmacology Leucine / metabolism Mice Protein Biosynthesis* Trialkyltin Compounds / antagonists & inhibitors, toxicity* |
| Chemical | |
Reg. No./Substance:
|
0/Trialkyltin Compounds; 3483-12-3/Dithiothreitol; 56-65-5/Adenosine Triphosphate; 61-90-5/Leucine; 688-73-3/tributyltin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term exposure of rats to perchloroethylene, with and without a post-exposure solvent-free recov...
Next Document: Long-term behavioral and learning abnormalities produced by the irreversible cholinesterase inhibito...