Document Detail

Reversibility of the endothelial dysfunction after CPAP therapy in OSAS patients.
MedLine Citation:
PMID:  21353713     Owner:  NLM     Status:  Publisher    
BACKGROUND: The obstructive sleep apnoea syndrome (OSAS) is a common airways disease which often involves cardiovascular structures, causing vessel inflammation as well as hypoxia, induced by difficulties in the passage of air through the upper airways. Aim of our research is to evaluate the effects of Continuous Positive Airway Pressure (CPAP) on the syndrome itself and the patients cardiovascular risk profile, practically adopting Flow-Mediated Vasodilation (FMD) technique to evaluate endothelial function. METHODS AND RESULTS: We enrolled 63 patients (49 males and 14 female, mean age: 54±10years) subdivided into four groups: high cardiovascular risk factors, no CPAP therapy, CPAP therapy started less- and more than 3months before. The patients underwent FMD of the brachial artery using a high resolution ultrasonograph connected to an image analysis system. The maximum recovery value was calculated as the ratio (maximum-baseline) of the change in diameter over the baseline value. Data obtained from this study demonstrate the significant reversibility of FMD in patients treated for more than 3months with CPAP therapy (Group 4). CONCLUSIONS: Our study shows the importance of administering CPAP therapy for more than 3months in patients suffering from OSAS to improve EF to a level equal to high cardiovascular risk subjects probably due to a recovery from the systemic hypoxia. Besides, our work points out the importance of FMD as a "clinical" tool able to point out any improvement or regression after therapies.
Marco Matteo Ciccone; Stefano Favale; Pietro Scicchitano; Francesco Mangini; Gianfranco Mitacchione; Felice Gadaleta; Daniela Longo; Massimo Iacoviello; Cinzia Forleo; Giovanni Quistelli; Stefano Taddei; Onofrio Resta; Pierluigi Carratù
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-24
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Department of Cardiology, University of Bari, Italy.
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