Document Detail


Reversibility and efficiency in coding protein information.
MedLine Citation:
PMID:  20868696     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Why the genetic code has a fixed length? Protein information is transferred by coding each amino acid using codons whose length equals 3 for all amino acids. Hence the most probable and the least probable amino acid get a codeword with an equal length. Moreover, the distributions of amino acids found in nature are not uniform and therefore the efficiency of such codes is sub-optimal. The origins of these apparently non-efficient codes are yet unclear. In this paper we propose an a priori argument for the energy efficiency of such codes resulting from their reversibility, in contrast to their time inefficiency. Such codes are reversible in the sense that a primitive processor, reading three letters in each step, can always reverse its operation, undoing its process. We examine the codes for the distributions of amino acids that exist in nature and show that they could not be both time efficient and reversible. We investigate a family of Zipf-type distributions and present their efficient (non-fixed length) prefix code, their graphs, and the condition for their reversibility. We prove that for a large family of such distributions, if the code is time efficient, it could not be reversible. In other words, if pre-biotic processes demand reversibility, the protein code could not be time efficient. The benefits of reversibility are clear: reversible processes are adiabatic, namely, they dissipate a very small amount of energy. Such processes must be done slowly enough; therefore time efficiency is non-important. It is reasonable to assume that early biochemical complexes were more prone towards energy efficiency, where forward and backward processes were almost symmetrical.
Authors:
Boaz Tamir; Avner Priel
Related Documents :
14610086 - Amino acids and insulin control autophagic proteolysis through different signaling path...
23673156 - High-glucose levels reduce fatty acid oxidation and increase triglyceride accumulation ...
15339006 - Response to lysine intake in composition of body weight gain and efficiency of lysine u...
1893276 - Protein and amino acid nutrition of lactating dairy cattle.
26896 - Hydrogen ion production secondary to metabolism of sulfur-amino acids and organic acids.
4080796 - Nonsteroidal antiinflammatory agents. part 16: stereomeric 3-aryl-biphenylyl-hydroxy-pr...
Publication Detail:
Type:  Journal Article     Date:  2010-09-22
Journal Detail:
Title:  Journal of theoretical biology     Volume:  267     ISSN:  1095-8541     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  519-25     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Israel Institute for Advanced Research, Rehovot, Israel. canjlm@actcom.co.il
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Sin resolvase catalytic activity and oligomerization state are tightly coupled.
Next Document:  Mapping multivalued onto Boolean dynamics.