| Reversibility of echinocyte formation after contact of erythrocytes with various radiographic contrast media. | |
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MedLine Citation:
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PMID: 18503136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Various radiographic contrast media (RCM) significantly influence the morphology of erythrocytes, especially the formation of echinocytes [Scand. J. Clin. Lab. Invest. 35 (1975), 1-43; Microvasc. Res. 60 (2000), 193-200; Herz 23 (2003), 35-41]. Microscopic studies, however, have shown that these changes of erythrocyte morphology are possibly reversible [Acta Radiol. 37 (1996), 214-217]. The aim of this study was to proof if the RCM-induced echinocyte formation can be reversed by a resuspension in autologous plasma. In this study four RCMs were tested (Iodixanol, Iohexol, Iomeprol and Iopromide). These RCM induced echinocyte formation (after suspension of erythrocytes in plasma/RCM mixtures for 10 min at 37 degrees C), which was reversible after resuspension in autologous RCM-free plasma (resuspension time 5 min at 37 degrees C). Especially for Iomeprol and Iopromide - the RCMs which induced the strongest echinocyte formation - an echinocyte reduction from 94.2% to 44.5% and for Iopromide from 80.6% to 50.4% occurred. The echinocyte formation was influenced by the type of RCM as well as by the RCM concentration. The same was true for the reversibility of echinocyte formation due to resuspension in autologous plasma (type of RCM: p</=0.0001; concentration of RCM: p=0.0847). Iodixanol was associated with the least numbers echinocytes formed (after suspension in the plasma/RCM-mixture as well as after the resuspension in autologous plasma). A 100% reversibility back to discocytes was observed in none of the RCMs after resuspension in autologous RCM-free plasma.In conclusion, a significant reversibility of RCM-induced echinocyte formation in autologous plasma could be observed. |
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Authors:
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C Mrowietz; B Hiebl; R P Franke; J-W Park; F Jung |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical hemorheology and microcirculation Volume: 39 ISSN: 1386-0291 ISO Abbreviation: Clin. Hemorheol. Microcirc. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-05-26 Completed Date: 2008-08-20 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 9709206 Medline TA: Clin Hemorheol Microcirc Country: Netherlands |
Other Details:
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Languages: eng Pagination: 281-6 Citation Subset: IM |
Affiliation:
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Institute for Heart and Circulation Research, Hoyerswerda, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cell Shape Contrast Media / pharmacology* Erythrocyte Count Erythrocyte Deformability Erythrocytes / drug effects* Female Humans Iohexol / analogs & derivatives, pharmacology Iopamidol / analogs & derivatives, pharmacology Male Oxygen / metabolism Temperature Triiodobenzoic Acids / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Triiodobenzoic Acids; 62883-00-5/Iopamidol; 66108-95-0/Iohexol; 73334-07-3/iopromide; 7782-44-7/Oxygen; 78649-41-9/iomeprol; 92339-11-2/iodixanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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