| Reversibility of the curdlan feeding effects on the morphological structure of intestinal mucosa in rats. | |
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MedLine Citation:
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PMID: 9919481 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We reported in the previous paper that rats fed a curdlan diet showed significant increases in the weight of the cecum and its contents, a decrease in fecal wet weight, a retardation in the transit time of the gastrointestinal tract and morphological changes of the ileal and cecal mucosal surface when compared with the rats fed a cellulose diet. In the present study, we intended to learn if the curdlan effects on the morphological structure of intestinal mucosa were reversible. When rats were fed on the curdlan diet for 2 weeks followed by a cellulose diet for another 2 weeks, the cecum and cecal contents were not different from those of the cellulose group. The transit time of the gastrointestinal tract of the curdlan-followed-by-cellulose group was shorter than that of the curdlan group, whereas it was longer than that of the cellulose group. In scanning electron micrographs, the ileal villi of the curdlan-followed-by-cellulose group were normal, as in the cellulose group. However, their ileal and cecal microvilli were similar to those of the curdlan group, that is, the microvilli were crowded and more tightly packed, and some appeared to have been squeezed out. From these results, it was concluded that the effects of the curdlan feeding were only partially reversible, but the effects on the surface structure of intestinal mucosa were still sustained even after curdlan feeding of 2 weeks was discontinued. This might result from response to the high viscosity of the intestinal contents remaining after discontinuation of the curdlan. |
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Authors:
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M Tetsuguchi; Y Yamashita; M Katayama; Y Sugawa-Katayama |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nutritional science and vitaminology Volume: 44 ISSN: 0301-4800 ISO Abbreviation: J. Nutr. Sci. Vitaminol. Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1999-03-18 Completed Date: 1999-03-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0402640 Medline TA: J Nutr Sci Vitaminol (Tokyo) Country: JAPAN |
Other Details:
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Languages: eng Pagination: 601-12 Citation Subset: IM |
Affiliation:
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Department of Food and Nutrition, Faculty of Human Life Science, Osaka City University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cecum / ultrastructure Cellulose / administration & dosage Colon / ultrastructure DNA / metabolism Dietary Fiber / adverse effects* Feces Gastrointestinal Transit Glucans / administration & dosage, adverse effects* Ileum / ultrastructure Intestinal Mucosa / metabolism, ultrastructure* Male Microscopy, Electron, Scanning Microvilli / ultrastructure Organ Size Polysaccharides, Bacterial Proteins / metabolism Rats Rats, Sprague-Dawley beta-Glucans* |
| Chemical | |
Reg. No./Substance:
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0/Glucans; 0/Polysaccharides, Bacterial; 0/Proteins; 0/beta-Glucans; 54724-00-4/curdlan; 9004-34-6/Cellulose; 9007-49-2/DNA |
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