Document Detail

Reversibility of chronic alcohol cardiac depression: 31P magnetic resonance spectroscopy in hamsters.
MedLine Citation:
PMID:  2709999     Owner:  NLM     Status:  MEDLINE    
In order to investigate the reversibility of chronic alcohol cardiac depression, hamsters were fed with 50% ethanol for 3 1/2 months, reaching serum alcohol levels of 0.13 +/- 0.11 g/dl (mean +/- SD). Alcohol was then withdrawn for 2 days. Isolated hearts were perfused according to a modified Langendorff method. Energy metabolites were studied using 31P magnetic resonance spectroscopy of isolated perfused hearts standardized by HPLC analysis of freeze-clamped tissue. Total intracellular calcium [Ca2+]i was measured with atomic absorption spectrophotometry, marking the extracellular space in vivo with K(CoEDTA). In alcohol-treated hamster hearts developed pressure was significantly depressed compared to controls. End-diastolic pressure was significantly increased. Coronary flow was not changed, whereas oxygen consumption and high-energy phosphate levels were significantly depressed. Intracellular pH was significantly decreased. [Ca2+]i was significantly increased. Heart weights were significantly lower. After alcohol withdrawal ventricular function, high-energy phosphate levels, and [Ca2+]i were not significantly different from control. The results indicate that chronic alcohol consumption depresses ventricular function and energy levels and also leads to myocardial acidosis. The increase in intracellular calcium likely causes mitochondrial dysfunction. Withdrawal of alcohol is associated with reversibility of functional and energetic cardiac depression.
W Auffermann; S Wu; W W Parmley; C B Higgins; J Wikman-Coffelt
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  9     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-06-08     Completed Date:  1989-06-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  343-52     Citation Subset:  IM    
Department of Radiology, University of California, San Francisco 94143.
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MeSH Terms
Body Water / metabolism
Calcium / metabolism*
Cardiomyopathy, Alcoholic / metabolism*,  physiopathology
Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy / diagnostic use
Myocardium / metabolism
Oxygen Consumption
Reg. No./Substance:

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