| Reversibility of canthaxanthin deposits within the retina. | |
| | |
MedLine Citation:
|
PMID: 2125796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
As reported earlier, crystalline yellow-glistening deposits in the retinal inner layer were identified in 22 of 53 patients treated with PHENORO (containing 10 mg beta-carotene and 15 mg canthaxanthin per capsule) for various light sensitive dermatoses at cumulative doses of canthaxanthin of up to 178 g for up to 12 years. 14 of the 22 patients with deposits could now be investigated again, 5 years after discontinuation of treatment. There was an extensive reduction of the number of deposits, confirming other reports which have demonstrated that the formation of the crystalline deposits is reversible. Analysis of serum samples revealed significant concentrations of canthaxanthin, resulting from the intake of this carotenoid via food. |
| | |
Authors:
|
H Leyon; A M Ros; S Nyberg; P Algvere |
Related Documents
:
|
4092616 - Toxicology of tetraethylene glycol di-n-heptanoate. 12107606 - Pharmacokinetics of beclomethasone 17-monopropionate from a beclomethasone dipropionate... 9250256 - Results of the first u.s. double-blind, placebo-controlled, multicenter clinical study ... 10667036 - Clinical and pharmacological aspects of accidental triamcinolone acetonide overdosage: ... 8511506 - Gastric and pancreatic lipase levels during a test meal in dogs. 10667616 - The effects of the novel anxiolytic drug lesopitron, a full and selective 5-ht1a recept... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta ophthalmologica Volume: 68 ISSN: 0001-639X ISO Abbreviation: Acta Ophthalmol (Copenh) Publication Date: 1990 Oct |
Date Detail:
|
Created Date: 1991-02-22 Completed Date: 1991-02-22 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370347 Medline TA: Acta Ophthalmol (Copenh) Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 607-11 Citation Subset: IM |
Affiliation:
|
Department of Ophthalmology, Sahlgrenska Hospital, Göteborg, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Canthaxanthin Carotenoids / adverse effects*, analogs & derivatives*, blood, metabolism, therapeutic use Crystallization Dose-Response Relationship, Drug Drug Combinations Female Fundus Oculi Humans Liver Function Tests Male Middle Aged Photosensitivity Disorders / drug therapy Prevalence Retina / metabolism* Retinal Diseases / chemically induced*, metabolism, therapy Visual Acuity / drug effects beta Carotene* |
| Chemical | |
Reg. No./Substance:
|
0/Drug Combinations; 36-88-4/Carotenoids; 514-78-3/Canthaxanthin; 54650-04-3/phenoro; 7235-40-7/beta Carotene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of sympathetic activity in initiating malignant hyperthermia.
Next Document: Umbilical plasma erythropoietin, hematocrits and their relationship to umbilical arterial blood gas,...