Document Detail

Reversibility of abnormal arterial baroreflex control of heart rate in heart failure.
MedLine Citation:
PMID:  6795939     Owner:  NLM     Status:  MEDLINE    
The reversibility of the abnormalities in arterial baroreceptor control of heart rate in heart failure was examined in an experimental model of canine high-output biventricular failure produced by an arteriovenous fistula that could be later surgically corrected by ligation. Marked attenuation of arterial baroreceptor control of heart rate in response to both hypertensive and hypotensive stimuli was seen in this model of heart failure. After surgical correction the heart rate response to a hypertensive stimulus did not return to normal but remained severely blunted for up to 8 mo of follow-up. The lack of reversibility after surgical correction suggests that permanent structural changes in arterial baroreceptors may occur after heart failure of short duration.
C W White
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  241     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1982-01-28     Completed Date:  1982-01-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H778-82     Citation Subset:  IM    
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MeSH Terms
Arteries / physiopathology*
Blood Pressure / drug effects
Heart Failure / physiopathology*
Heart Rate* / drug effects
Heart Ventricles / physiopathology
Nitroglycerin / pharmacology
Phenylephrine / pharmacology
Pressoreceptors / drug effects,  physiopathology*
Grant Support
Reg. No./Substance:
55-63-0/Nitroglycerin; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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