| Reversed transport of amino acids in Ehrlich cells. | |
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MedLine Citation:
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PMID: 53074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gramicidin induces a marked Na+-dependent efflux of amino acids from Ehrlich cells. In absence of Na+, gramicidin does not alter the efflux. In presence gramicidin, glycine efflux is inhibited by methionine and less so by leucine. Glycine efflux caused by HgCl2 is neither Na+ dependent nor inhibitable by amino acids. Neither efflux of inositol which is transported by an Na+-dependent route, nor efflux of several other solutes which are transported by Na+-independent routes, is affected by gramicidin. The antibiotic appears to permit a reversal in the direction of of the operation of the Na+-dependent amino acid transport system. The increased efflux is partly, but not entirely, due to an increase in the cellular Na+ concentration and a reduction of the electrochemical potential difference for Na+. |
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Authors:
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R M Johnstone |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 413 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1975 Dec |
Date Detail:
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Created Date: 1976-02-21 Completed Date: 1976-02-21 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 252-64 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism* Animals Biological Transport Carcinoma, Ehrlich Tumor / metabolism* Cell Membrane / drug effects, metabolism Glycine / metabolism Gramicidin / pharmacology Inositol / metabolism Kinetics Mice Sodium / pharmacology Temperature |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 1405-97-6/Gramicidin; 56-40-6/Glycine; 6917-35-7/Inositol; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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