Document Detail

Reversed transport of amino acids in Ehrlich cells.
MedLine Citation:
PMID:  53074     Owner:  NLM     Status:  MEDLINE    
Gramicidin induces a marked Na+-dependent efflux of amino acids from Ehrlich cells. In absence of Na+, gramicidin does not alter the efflux. In presence gramicidin, glycine efflux is inhibited by methionine and less so by leucine. Glycine efflux caused by HgCl2 is neither Na+ dependent nor inhibitable by amino acids. Neither efflux of inositol which is transported by an Na+-dependent route, nor efflux of several other solutes which are transported by Na+-independent routes, is affected by gramicidin. The antibiotic appears to permit a reversal in the direction of of the operation of the Na+-dependent amino acid transport system. The increased efflux is partly, but not entirely, due to an increase in the cellular Na+ concentration and a reduction of the electrochemical potential difference for Na+.
R M Johnstone
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  413     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1975 Dec 
Date Detail:
Created Date:  1976-02-21     Completed Date:  1976-02-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  252-64     Citation Subset:  IM    
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MeSH Terms
Amino Acids / metabolism*
Biological Transport
Carcinoma, Ehrlich Tumor / metabolism*
Cell Membrane / drug effects,  metabolism
Glycine / metabolism
Gramicidin / pharmacology
Inositol / metabolism
Sodium / pharmacology
Reg. No./Substance:
0/Amino Acids; 1405-97-6/Gramicidin; 56-40-6/Glycine; 6917-35-7/Inositol; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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